O-IODO FLUOROBENZENE
2-Fluoroiodobenzene
CAS: 348-52-7
Molecular Formula: C6H4FI
O-IODO FLUOROBENZENE - Names and Identifiers
O-IODO FLUOROBENZENE - Physico-chemical Properties
| Molecular Formula | C6H4FI |
| Molar Mass | 222 |
| Density | 1.903g/mLat 25°C(lit.) |
| Melting Point | −41-−40°C(lit.) |
| Boling Point | 188-189°C(lit.) |
| Flash Point | 160°F |
| Vapor Presure | 0.791mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.903 |
| Color | Clear light yellow |
| BRN | 2039770 |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Sensitive | Light Sensitive |
| Refractive Index | n20/D 1.59(lit.) |
O-IODO FLUOROBENZENE - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN3082 - class 9 - PG 3 - DOT NA1993 - Environmentally hazardous substances, liquid, n.o.s. HI: all (not BR) |
| WGK Germany | 2 |
| TSCA | T |
| HS Code | 29039990 |
| Hazard Class | IRRITANT |
O-IODO FLUOROBENZENE - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Use | 2-fluoroiodobenzene is an organic intermediate, such as it can be used to prepare aniline derivatives 2-fluoro-3-iodoaniline, 2-Fluoro-3-iodoaniline can be used to synthesize antidepressant, antitumor, and antibacterial drugs. |
| Preparation | 2-fluoroiodobenzene, which can be prepared from 2-fluoroaniline through one-step reaction. At room temperature, NaNO2(0.151g,2.2 mmol) and N-iodosuccinimide (0.337g,1.5 mmol) were added to a stirred solution of 2-fluoroaniline (1.5 mmol) in DMF(6 mL). Continue to react for 4 hours. Na2S2O3(10% w/w aqueous solution, 10 mL) was added to quench the reaction. The resulting mixture was extracted with EtOAc(3 × 20mL). The combined organic fraction was dried with anhydrous Na2SO4. Vacuum removes the solvent to get the residue. The residue was purified by silica gel column chromatography using hexane/EtOAc(9.5:0.5,v/v) as eluent to obtain 2-fluoroiodobenzene. |
Last Update：2024-04-09 21:04:16
